Measuring Transcription Factor–Binding Site Turnover: A Maximum Likelihood Approach Using Phylogenies

A major mode of gene expression evolution is based on changes in cis-regulatory elements (CREs) whose function critically depends on the presence of transcription factor–binding sites (TFBS). Because CREs experience extensive TFBS turnover even with conserved function, alignment-based studies of CRE...

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Bibliographic Details
Main Authors: Otto, Wolfgang, Stadler, Peter F., López-Giraldéz, Francesc, Townsend, Jeffrey P., Lynch, Vincent J., Wagner, Günter P.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2009
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2817405/
https://ncbi.nlm.nih.gov/pubmed/20333180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gbe/evp010
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