Potent, transient inhibition of BCR-ABL with dasatinib 100 mg daily achieves rapid and durable cytogenetic responses and high transformation-free survival rates in chronic phase chronic myeloid leukemia patients with resistance, suboptimal response or intolerance to imatinib

BACKGROUND: Dasatinib 100 mg once daily achieves intermittent BCR-ABL kinase inhibition and is approved for chronic-phase chronic myeloid leukemia patients resistant or intolerant to imatinib. To better assess durability of response to and tolerability of dasatinib, data from a 2-year minimum follow...

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Main Authors: Shah, Neil P., Kim, Dong-Wook, Kantarjian, Hagop, Rousselot, Philippe, Llacer, Pedro Enrique Dorlhiac, Enrico, Alicia, Vela-Ojeda, Jorge, Silver, Richard T., Khoury, Hanna Jean, Müller, Martin C., Lambert, Alexandre, Matloub, Yousif, Hochhaus, Andreas
Format: Artigo
Sprog:Inglês
Udgivet: Ferrata Storti Foundation 2010
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2817025/
https://ncbi.nlm.nih.gov/pubmed/20139391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2009.011452
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