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Active site-directed inhibition of Ca2+/calmodulin-dependent protein kinase type II by a bifunctional calmodulin-binding peptide.

The activation of Ca2+/calmodulin (CaM)-dependent protein kinase II (CaM-KII) by Ca2+/CaM results in autophosphorylation and the generation of Ca2+/CaM-independent enzyme activity. We postulated that CaM binding and subsequent autophosphorylation alters the conformation of CaM-KII and exposes its su...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Kelly, P T, Weinberger, R P, Waxham, M N
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 1988
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Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC281673/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3134656/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.14.4991
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