A Variant of TNFR2-Fc Fusion Protein Exhibits Improved Efficacy in Treating Experimental Rheumatoid Arthritis

Etanercept, a TNF receptor 2-Fc fusion protein, is currently being used for the treatment of rheumatoid arthritis (RA). However, 25% to 38% of patients show no response which is suspected to be partially due to insufficient affinity of this protein to TNFα. By using computational protein design, we...

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Detalhes bibliográficos
Main Authors: Yang, Tong, Wang, Zheng, Wu, Fang, Tan, Jingwei, Shen, Yijun, Li, Erguang, Dai, Jingzhi, Shen, Ronghai, Li, Gang, Wu, Jinsong, Wang, Luochun, Wang, Haibo, Liu, Yanjun
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2816690/
https://ncbi.nlm.nih.gov/pubmed/20140191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000669
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