Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis

Farnesoid X receptor (FXR) is a bile acid–activated transcription factor that is a member of the nuclear hormone receptor superfamily. Fxr-null mice exhibit a phenotype similar to Byler disease, an inherited cholestatic liver disorder. In the liver, activation of FXR induces transcription of transpo...

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Main Authors: Liu, Yaping, Binz, Jane, Numerick, Mary Jo, Dennis, Steve, Luo, Guizhen, Desai, Bhasha, MacKenzie, Kathleen I., Mansfield, Traci A., Kliewer, Steven A., Goodwin, Bryan, Jones, Stacey A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2003
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC281645/
https://ncbi.nlm.nih.gov/pubmed/14623915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200318945
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