Acute myeloid leukemia fusion proteins deregulate genes involved in stem cell maintenance and DNA repair

Acute myelogenous leukemias (AMLs) are genetically heterogeneous and characterized by chromosomal rearrangements that produce fusion proteins with aberrant transcriptional regulatory activities. Expression of AML fusion proteins in transgenic mice increases the risk of myeloid leukemias, suggesting...

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Detalhes bibliográficos
Main Authors: Alcalay, Myriam, Meani, Natalia, Gelmetti, Vania, Fantozzi, Anna, Fagioli, Marta, Orleth, Annette, Riganelli, Daniela, Sebastiani, Carla, Cappelli, Enrico, Casciari, Cristina, Sciurpi, Maria Teresa, Mariano, Angela Rosa, Minardi, Simone Paolo, Luzi, Lucilla, Muller, Heiko, Di Fiore, Pier Paolo, Frosina, Guido, Pelicci, Pier Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2003
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC281638/
https://ncbi.nlm.nih.gov/pubmed/14660751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200317595
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