Generation of Dopamine Neurons with Improved Cell Survival and Phenotype Maintenance Using a Degradation-Resistant Nurr1 Mutant

Nurr1 is a transcription factor specific for the development and maintenance of the midbrain dopamine (DA) neurons. Exogenous Nurr1 in neural precursor (NP) cells induces the differentiation of DA neurons in vitro that are capable of reversing motor dysfunctions in a rodent model for Parkinson disea...

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Detalhes bibliográficos
Main Authors: Jo, A-Young, Kim, Mi-Young, Lee, Hyun-Seob, Rhee, Yong-Hee, Lee, Jeong-Eun, Baek, Kwang-Hyun, Park, Chang-Hwan, Koh, Hyun-Chul, Shin, Incheol, Lee, Yong-Sung, Lee, Sang-Hun
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Subscription Services, Inc., A Wiley Company 2009
Assuntos:
Tissue-Specific Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2816355/
https://ncbi.nlm.nih.gov/pubmed/19522012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.146
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