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Drosophila melanogaster p53 has developmental stage-specific and sex-specific effects on adult life span indicative of sexual antagonistic pleiotropy

Truncated and mutant forms ofp53 affect life span in Drosophila, nematodes and mice, however the role of wild-type p53 in aging remains unclear. Here conditional over-expression of both wild-type and mutant p53 transgenes indicated that, in adult flies, p53 limits life span in females but favors lif...

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Autors principals: Waskar, Morris, Landis, Gary N., Shen, Jie, Curtis, Christina, Tozer, Kevin, Abdueva, Diana, Skvortsov, Dmitriy, Tavaré, Simon, Tower, John
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2815744/
https://ncbi.nlm.nih.gov/pubmed/20157574
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