Phase I Study of Intravenous Vascular Endothelial Growth Factor Trap, Aflibercept, in Patients With Advanced Solid Tumors

PURPOSE: Vascular endothelial growth factor (VEGF) Trap (aflibercept) is an angiogenesis inhibitor comprising portions of the extracellular domains of human VEGF receptors 1 and 2 fused to the Fc portion of human immunoglobulin G. This phase I study was designed to evaluate the safety, pharmacokinet...

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Bibliographische Detailangaben
Hauptverfasser: Lockhart, A. Craig, Rothenberg, Mace L., Dupont, Jakob, Cooper, Wendy, Chevalier, Paul, Sternas, Lars, Buzenet, Giliane, Koehler, Elizabeth, Sosman, Jeffrey A., Schwartz, Lawrence H., Gultekin, David H., Koutcher, Jason A., Donnelly, Edwin F., Andal, Ric, Dancy, Isabelle, Spriggs, David R., Tew, William P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Clinical Oncology 2010
Schlagworte:
Original Reports
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2815710/
https://ncbi.nlm.nih.gov/pubmed/19949018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2009.22.9237
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