Phase II Trial of Infusional Fluorouracil, Irinotecan, and Bevacizumab for Metastatic Colorectal Cancer: Efficacy and Circulating Angiogenic Biomarkers Associated With Therapeutic Resistance

PURPOSE: We investigated the efficacy of fluorouracil (FU), leucovorin, irinotecan, and bevacizumab (FOLFIRI + B) in a phase II trial in patients previously untreated for metastatic colorectal cancer (mCRC), and changes during treatment in plasma cytokines and angiogenic factors (CAFs) as potential...

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Detalhes bibliográficos
Main Authors: Kopetz, Scott, Hoff, Paulo M., Morris, Jeffrey S., Wolff, Robert A., Eng, Cathy, Glover, Katrina Y., Adinin, Rosie, Overman, Michael J., Valero, Vincete, Wen, Sijin, Lieu, Christopher, Yan, Shaoyu, Tran, Hai T., Ellis, Lee M., Abbruzzese, James L., Heymach, John V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2010
Assuntos:
Original Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2815707/
https://ncbi.nlm.nih.gov/pubmed/20008624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2009.24.8252
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