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Single-unit dominance after double-unit umbilical cord blood transplantation coincides with a specific CD8(+) T-cell response against the nonengrafted unit

We investigated the potential role of an immune reaction in mediating the dominant engraftment of 1 cord blood unit in 14 patients who received a double-unit cord blood transplantation (CBT). In 10 patients, dominant engraftment of a single donor unit emerged by day 28 after CBT. In 9 of these 10 pa...

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Detalhes bibliográficos
Main Authors: Gutman, Jonathan A., Turtle, Cameron J., Manley, Thomas J., Heimfeld, Shelly, Bernstein, Irwin D., Riddell, Stanley R., Delaney, Colleen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2815516/
https://ncbi.nlm.nih.gov/pubmed/19822900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-07-228999
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