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Synthesis of Novel Pyrazoles via [2+3]-Dipolar Cycloaddition Using Alkyne Surrogates

The syntheses of an important class of hitherto unreported novel pyrazoles are described. The regioselective synthesis of 1,3,4,5-tetrasubstituted pyrazoles was achieved by the Huisgen cyclization of nitrile imines with a trisubstituted bromoalkene. The substituted bromoalkene functions as an alkyne...

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Autors principals: Dadiboyena, Sureshbabu, Valente, Edward J., Hamme, Ashton T.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2814424/
https://ncbi.nlm.nih.gov/pubmed/20161634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2010.01.017
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