Deoxycholate, an Endogenous Cytotoxin/Genotoxin, Induces the Autophagic Stress-Survival Pathway: Implications for Colon Carcinogenesis

We report that deoxycholate (DOC), a hydrophobic bile acid associated with a high-fat diet, activates the autophagic pathway in non-cancer colon epithelial cells (NCM-460), and that this activation contributes to cell survival. The DOC-induced increase in autophagy was documented by an increase in a...

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Detalhes bibliográficos
Main Authors: Payne, Claire M., Crowley-Skillicorn, Cheray, Holubec, Hana, Dvorak, Katerina, Bernstein, Carol, Moyer, Mary Pat, Garewal, Harinder, Bernstein, Harris
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2814131/
https://ncbi.nlm.nih.gov/pubmed/20130808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2009/785907
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