Antidepressant-Like Effects of κ-Opioid Receptor Antagonists in Wistar Kyoto Rats

The Wistar Kyoto (WKY) rat strain is a putative genetic model of comorbid depression and anxiety. Previous research showing increased κ-opioid receptor (KOR) gene expression in the brains of WKY rats, combined with studies implicating the KOR in animal models of depression and anxiety, suggests that...

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Main Authors: Carr, Gregory V, Bangasser, Debra A, Bethea, Thelma, Young, Matthew, Valentino, Rita J, Lucki, Irwin
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2010
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2813986/
https://ncbi.nlm.nih.gov/pubmed/19924112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2009.183
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