A phase I pharmacological and biological study of PI-88 and docetaxel in patients with advanced malignancies

PURPOSE: This study evaluated the safety, toxicity, pharmacological properties and biological activity of PI-88, a heparanase endoglycosidase enzyme inhibitor, with fixed weekly docetaxel in patients with advanced solid malignancies. EXPERIMENTAL DESIGN: This was a phase I study to determine the max...

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Detalhes bibliográficos
Main Authors: Chow, Laura Q. M., Gustafson, Daniel L., O’Bryant, Cindy L., Gore, Lia, Basche, Michele, Holden, Scott N., Morrow, Mark C., Grolnic, Stacy, Creese, Brian R., Roberts, Kaye L., Davis, Kat, Addison, Russell, Eckhardt, S. Gail
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2813677/
https://ncbi.nlm.nih.gov/pubmed/18320191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-008-0712-z
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