Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus

Monozygotic (MZ) twins are partially concordant for most complex diseases, including autoimmune disorders. Whereas phenotypic concordance can be used to study heritability, discordance suggests the role of non-genetic factors. In autoimmune diseases, environmentally driven epigenetic changes are tho...

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Detalhes bibliográficos
Main Authors: Javierre, Biola M., Fernandez, Agustin F., Richter, Julia, Al-Shahrour, Fatima, Martin-Subero, J. Ignacio, Rodriguez-Ubreva, Javier, Berdasco, Maria, Fraga, Mario F., O'Hanlon, Terrance P., Rider, Lisa G., Jacinto, Filipe V., Lopez-Longo, F. Javier, Dopazo, Joaquin, Forn, Marta, Peinado, Miguel A., Carreño, Luis, Sawalha, Amr H., Harley, John B., Siebert, Reiner, Esteller, Manel, Miller, Frederick W., Ballestar, Esteban
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2010
Assuntos:
Letter
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2813473/
https://ncbi.nlm.nih.gov/pubmed/20028698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.100289.109
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