Flecainide inhibits arrhythmogenic Ca(2+) waves by open state block of ryanodine receptor Ca(2+) release channels and reduction of Ca(2+) spark mass

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is linked to mutations in the cardiac ryanodine receptor (RyR2) or calsequestrin. We recently found that the drug flecainide inhibits RyR2 channels and prevents CPVT in mice and humans. Here we compared the effects of flecainide and tetrac...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Hilliard, Fredrick A., Steele, Derek S., Laver, Derek, Yang, Zhaokang, Le Marchand, Sylvain J., Chopra, Nagesh, Piston, David W., Huke, Sabine, Knollmann, Björn C.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2009
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2813417/
https://ncbi.nlm.nih.gov/pubmed/19835880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2009.10.005
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia