CD28 Down-Regulation on Circulating CD4 T-Cells Is Associated with Poor Prognoses of Patients with Idiopathic Pulmonary Fibrosis

BACKGROUND: Although the etiology of idiopathic pulmonary fibrosis (IPF) remains perplexing, adaptive immune activation is evident among many afflicted patients. Repeated cycles of antigen-induced proliferation cause T-cells to lose surface expression of CD28, and we hypothesized this process might...

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Main Authors: Gilani, Syed R., Vuga, Louis J., Lindell, Kathleen O., Gibson, Kevin F., Xue, Jianmin, Kaminski, Naftali, Valentine, Vincent G., Lindsay, Emily K., George, M. Patricia, Steele, Chad, Duncan, Steven R.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2813297/
https://ncbi.nlm.nih.gov/pubmed/20126467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008959
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