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Evaluation of the phosphodiesterase 3 inhibitor ORG 9935 as a contraceptive in female macaques: Initial trials

BACKGROUND: The study was conducted to determine whether a phosphodiesterase (PDE) 3 inhibitor has potential as a novel contraceptive in primates. METHODS: Regularly cycling adult female cynomolgus macaques of proven fertility (n=16) were treated for 7 months with placebo (controls) or the PDE 3 inh...

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Autors principals: Jensen, Jeffrey T., Stouffer, Richard L., Stanley, Jessica E., Zelinski, Mary B.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2813210/
https://ncbi.nlm.nih.gov/pubmed/20103457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.contraception.2009.09.015
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