The intestine-specific transcription factor Cdx2 inhibits β-catenin/TCF transcriptional activity by disrupting the β-catenin–TCF protein complex

Cdx2 is an intestine-specific transcription factor known to regulate proliferation and differentiation. We have reported previously that Cdx2 limits the proliferation of human colon cancer cells by inhibiting the transcriptional activity of the β-catenin–T-cell factor (TCF) bipartite complex. Herein...

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Bibliographic Details
Main Authors: Guo, Rong-Jun, Funakoshi, Shinsuke, Lee, Hannah H., Kong, Jianping, Lynch, John P.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2010
Subjects:
Cancer Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812568/
https://ncbi.nlm.nih.gov/pubmed/19734199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgp213
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