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Adenosine A(2A) receptor activation limits graft-versus-host disease after allogenic hematopoietic stem cell transplantation

GVHD is a major barrier to broader use of allogenic HSCT for nonmalignancy clinical applications such as the treatment of primary immunodeficiencies and hemoglobinopathies. We show in a murine model of C57BL/6J (H2-k(b)) → B6D2F1/J (H2-k(b/d)) acute GVHD that when initiated 2 days before transplant,...

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Detalhes bibliográficos
Main Authors: Lappas, Courtney M., Liu, Po-Ching, Linden, Joel, Kang, Elizabeth M., Malech, Harry L.
Formato: Artigo
Idioma:Inglês
Publicado em: The Society for Leukocyte Biology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812560/
https://ncbi.nlm.nih.gov/pubmed/19889728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0609388
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