Vaccination with an Adenoviral Vector That Encodes and Displays a Retroviral Antigen Induces Improved Neutralizing Antibody and CD4(+) T-Cell Responses and Confers Enhanced Protection

We present a new type of adenoviral vector that both encodes and displays a vaccine antigen on the capsid, thus combining in itself gene-based and protein vaccination; this vector resulted in an improved vaccination outcome in the Friend virus (FV) model. For presentation of the envelope protein gp7...

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Detalhes bibliográficos
Main Authors: Bayer, Wibke, Tenbusch, Matthias, Lietz, Ruth, Johrden, Lena, Schimmer, Simone, Überla, Klaus, Dittmer, Ulf, Wildner, Oliver
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812386/
https://ncbi.nlm.nih.gov/pubmed/20007267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01840-09
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