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Cellular Immune Responses to Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) Infection in Senescent BALB/c Mice: CD4(+) T Cells Are Important in Control of SARS-CoV Infection

We characterized the cellular immune response to severe acute respiratory syndrome coronavirus (SARS-CoV) infection in 12- to 14-month-old BALB/c mice, a model that mimics features of the human disease. Following intranasal administration, the virus replicated in the lungs, with peak titers on day 2...

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Autors principals: Chen, Jun, Lau, Yuk Fai, Lamirande, Elaine W., Paddock, Christopher D., Bartlett, Jeanine H., Zaki, Sherif R., Subbarao, Kanta
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812346/
https://ncbi.nlm.nih.gov/pubmed/19906920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01281-09
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