Major Secretory Antigens of the Helminth Fasciola hepatica Activate a Suppressive Dendritic Cell Phenotype That Attenuates Th17 Cells but Fails To Activate Th2 Immune Responses

Fasciola hepatica is a helminth pathogen that drives Th2/Treg immune responses in its mammalian host. The parasite releases a large number of molecules that are critical to inducing this type of immune response. Here we have selected recombinant forms of two major F. hepatica secreted molecules, the...

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Detalhes bibliográficos
Main Authors: Dowling, David J., Hamilton, Clare M., Donnelly, Sheila, La Course, James, Brophy, Peter M., Dalton, John, O'Neill, Sandra M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812196/
https://ncbi.nlm.nih.gov/pubmed/19917714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00573-09
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