Influence of Alpha-1 Glycoprotein Acid Concentrations and Variants on Atazanavir Pharmacokinetics in HIV-Infected Patients Included in the ANRS 107 Trial

Atazanavir is an HIV-1 protease inhibitor with high protein binding in human plasma. The objectives were first to determine the in vitro binding characteristics of atazanavir and second to evaluate whether plasma protein binding to albumin and alpha-1 glycoprotein acid (AAG) influences the pharmacok...

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Main Authors: Barrail-Tran, A., Mentré, F., Cosson, C., Piketty, C., Chazallon, C., Gérard, L., Girard, P. M., Taburet, A. M.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology (ASM) 2010
主題:
Antiviral Agents
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812179/
https://ncbi.nlm.nih.gov/pubmed/19995932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00797-09
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