Defining Fractional Inhibitory Concentration Index Cutoffs for Additive Interactions Based on Self-Drug Additive Combinations, Monte Carlo Simulation Analysis, and In Vitro-In Vivo Correlation Data for Antifungal Drug Combinations against Aspergillus fumigatus

The fractional inhibitory concentration (FIC) index range of 0.5 to 4 that is commonly used to define additivity results in no interactions in most combination studies of antifungal agents. These results may differ from those of in vivo studies, where positive and negative interactions may be observ...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Meletiadis, Joseph, Pournaras, Spyros, Roilides, Emmanuel, Walsh, Thomas J.
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Microbiology (ASM) 2010
الموضوعات:
Susceptibility
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812160/
https://ncbi.nlm.nih.gov/pubmed/19995928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00999-09
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