Intranasal Immunization of Mice with a Bovine Respiratory Syncytial Virus Vaccine Induces Superior Immunity and Protection Compared to Those by Subcutaneous Delivery or Combinations of Intranasal and Subcutaneous Prime-Boost Strategies

Bovine respiratory syncytial virus (BRSV) infects cells of the respiratory mucosa, so it is desirable to develop a vaccination strategy that induces mucosal immunity. To achieve this, various delivery routes were compared for formalin-inactivated (FI) BRSV formulated with CpG oligodeoxynucleotide (O...

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Main Authors: Mapletoft, John W., Latimer, Laura, Babiuk, Lorne A., van Drunen Littel-van den Hurk, Sylvia
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2010
Teme:
Vaccine Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812083/
https://ncbi.nlm.nih.gov/pubmed/19864487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00250-09
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