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COMBINING MUTUAL INFORMATION WITH STRUCTURAL ANALYSIS TO SCREEN FOR FUNCTIONALLY IMPORTANT RESIDUES IN INFLUENZA HEMAGGLUTININ
Influenza hemagglutinin mediates both cell-surface binding and cell entry by the virus. Mutations to hemagglutinin are thus critical in determining host species specificity and viral infectivity. Previous approaches have primarily considered point mutations and sequence conservation; here we develop...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2009
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2811693/ https://ncbi.nlm.nih.gov/pubmed/19209725 |
| Oznake: |
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