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Mecamylamine Attenuates Cue-Induced Reinstatement of Nicotine-Seeking Behavior in Rats

Mecamylamine, a noncompetitive nicotinic cholinergic antagonist, inhibits nicotine self-administration in animals and may attenuate tobacco smoking in humans trying to quit. Our preliminary data suggested that this agent, at a dose of 2 mg/kg (subcutaneous (s.c.)), also attenuates cue-induced relaps...

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Detalhes bibliográficos
Main Authors: Liu, Xiu, Caggiula, Anthony R, Yee, Susan K, Nobuta, Hiroko, Sved, Alan F, Pechnick, Robert N, Poland, Russell E
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2811395/
https://ncbi.nlm.nih.gov/pubmed/16794568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.npp.1301129
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