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Hyper- and Hypo- Induction of Cytochrome P450 activities with Aroclor 1254 and 3-Methylcholanthrene in Cyp1a2(−/−) mice

The response of hepatic mono-oxygenase activities to Aroclor 1254 or 3-methylcholanthrene was investigated in wild-type and Cyp1a2(−/−) mice. Cytochrome P450 concentrations were similar in naïve Cyp1a2(−/−) and wild-type mice. There was no difference between naïve wild-type and Cyp1a2(−/−) animals i...

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Detalhes bibliográficos
Main Authors: Barker, Melissa L., Hathaway, Laura B., Arch, Dorinda D., Westbroek, Mark L., Kushner, James P., Phillips, John D., Franklin, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2811265/
https://ncbi.nlm.nih.gov/pubmed/19772856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2009.09.007
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