Chylomicronemia With a Mutant GPIHBP1 (Q115P) That Cannot Bind Lipoprotein Lipase

OBJECTIVE: GPIHBP1 is an endothelial cell protein that binds lipoprotein lipase (LPL) and chylomicrons. Because GPIHBP1 deficiency causes chylomicronemia in mice, we sought to determine whether some cases of chylomicronemia in humans could be attributable to defective GPIHBP1 proteins. METHODS AND R...

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Auteurs principaux: Beigneux, Anne P., Franssen, Remco, Bensadoun, André, Gin, Peter, Melford, Kristan, Peter, Jorge, Walzem, Rosemary L., Weinstein, Michael M., Davies, Brandon S.J., Kuivenhoven, Jan A., Kastelein, John J.P., Fong, Loren G., Dallinga-Thie, Geesje M., Young, Stephen G.
Format: Artigo
Langue:Inglês
Publié: 2009
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2811263/
https://ncbi.nlm.nih.gov/pubmed/19304573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.109.186577
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