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Geldanamycin promotes premature mitotic entry and micronucleation in irradiated p53/p21 deficient colon carcinoma cells
P53 wild-type and p53-null or mutant cells undergo a G2-phase cell cycle arrest in response to ionizing radiation (IR). In this study we examined the effect of heat shock protein 90 (HSP90) inhibitor geldanamycin (GA) on IR-induced G2 arrest in human colon adenocarcionoma cells with different p53 st...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2811229/ https://ncbi.nlm.nih.gov/pubmed/18504430 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2008.172 |
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