Protein Kinase A-Mediated Phosphorylation of cMyBP-C Increases Proximity of Myosin Heads to Actin in Resting Myocardium

Protein Kinase A-mediated (PKA) phosphorylation of cardiac myosin binding protein-C (cMyBP-C) accelerates the kinetics of cross-bridge cycling and may relieve the tether-like constraint of myosin heads imposed by cMyBP-C. We favor a mechanism in which cMyBP-C modulates cross-bridge cycling kinetics...

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Hlavní autoři: Colson, Brett A., Bekyarova, Tanya, Locher, Matthew R., Fitzsimons, Daniel P., Irving, Thomas C., Moss, Richard L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2810832/
https://ncbi.nlm.nih.gov/pubmed/18599866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.108.178996
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