Synthesis, characterization, and clinical evaluation of conjugate vaccines composed of the O-specific polysaccharides of Shigella dysenteriae type 1, Shigella flexneri type 2a, and Shigella sonnei (Plesiomonas shigelloides) bound to bacterial toxoids.

The theoretic basis for developing conjugate vaccines, to induce immunoglobulin G (IgG) lipopolysaccharide (LPS) antibodies for the prevention of shigellosis, has been described (J. B. Robbins, C.-Y. Chu, and R. Schneerson, Clin. Infect. Dis. 15:346-361, 1992). The O-specific polysaccharides (O-SPs)...

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Detalles Bibliográficos
Publicado en:Infect Immun
Main Authors: Taylor, D N, Trofa, A C, Sadoff, J, Chu, C, Bryla, D, Shiloach, J, Cohen, D, Ashkenazi, S, Lerman, Y, Egan, W
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 1993
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC281064/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8359890/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.61.9.3678-3687.1993
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