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Selective Toxin Sequestrants for the Treatment of Bacterial Infections

Bacterial toxin-mediated diarrheal disease is a major cause of morbidity and mortality worldwide. In this work we designed an on-bead library of protease-resistant, acid-stable peptoid molecules and screened for high affinity binding of cholera toxin. From 100,000 compounds, we discovered a single s...

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Main Authors: Simpson, Levi S., Burdine, Lyle, Dutta, Amal K., Feranchak, Andrew P., Kodadek, Thomas
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2810561/
https://ncbi.nlm.nih.gov/pubmed/19351156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja900852k
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