WASP plays a novel role in regulating platelet responses dependent on αIIbβ3 integrin outside-in signaling

The most consistent feature of Wiskott-Aldrich syndrome (WAS) is profound thrombocytopenia with small platelets. The responsible gene encodes WASP (WAS protein), which functions in leukocytes as an actin filament nucleating agent – yet – actin filament nucleation proceeds normally in patient platele...

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Autores principales: Shcherbina, Anna, Cooley, Jessica, Lutskiy, Maxim I., Benarafa, Charaf, Gilbert, Gary E., Remold-O’Donnell, Eileen
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2810352/
https://ncbi.nlm.nih.gov/pubmed/19863535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2141.2009.07959.x
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