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Understanding the Basis for the Association of apoE4 with Alzheimer’s Disease: Opening the Door for Therapeutic Approaches
Apolipoprotein E4 (apoE4) is the major genetic risk factor for Alzheimer’s disease (AD) by an as yet to be defined mechanism. Since the structure or biophysical properties of a protein directly determines function, our approach to addressing mechanism is structure:function based. Domain interaction...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2810311/ https://ncbi.nlm.nih.gov/pubmed/19874264 |
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