Role of the proteasome and NF-κB in streptococcal cell wall-induced polyarthritis

The transcription factor NF-κB activates a number of genes whose protein products are proinflammatory. In quiescent cells, NF-κB exists in a latent form and is activated via a signal-dependent proteolytic mechanism in which the inhibitory protein IκB is degraded by the ubiquitin–proteasome pathway....

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Detalhes bibliográficos
Main Authors: Palombella, Vito J., Conner, Elaine M., Fuseler, John W., Destree, Antonia, Davis, Jonathan M., Laroux, F. Stephen, Wolf, Robert E., Huang, Jianqing, Brand, Stephen, Elliott, Peter J., Lazarus, Douglas, McCormack, Teresa, Parent, Lana, Stein, Ross, Adams, Julian, Grisham, Matthew B.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1998
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC28102/
https://ncbi.nlm.nih.gov/pubmed/9861028
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