Pharmacologically Increased Tumor Hypoxia Can Be Measured by (18)F-Fluoroazomycin Arabinoside Positron Emission Tomography and Enhances Tumor Response to Hypoxic Cytotoxin PR-104

PURPOSE: Solid tumors contain microenvironmental regions of hypoxia that present a barrier to traditional radiotherapy and chemotherapy, and this work describes a novel approach to circumvent hypoxia. We propose to overcome hypoxia by augmenting the effectiveness of drugs that are designed to specif...

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Bibliographic Details
Main Authors: Cairns, Rob A., Bennewith, Kevin L., Graves, Edward E., Giaccia, Amato J., Chang, Daniel T., Denko, Nicholas C.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2810128/
https://ncbi.nlm.nih.gov/pubmed/19920111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-1676
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