Deleted in breast cancer–1 regulates SIRT1 activity and contributes to high-fat diet–induced liver steatosis in mice

The enzyme sirtuin 1 (SIRT1) is a critical regulator of many cellular functions, including energy metabolism. However, the precise mechanisms that modulate SIRT1 activity remain unknown. As SIRT1 activity in vitro was recently found to be negatively regulated by interaction with the deleted in breas...

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Detalhes bibliográficos
Main Authors: Escande, Carlos, Chini, Claudia C.S., Nin, Veronica, Dykhouse, Katherine Minter, Novak, Colleen M., Levine, James, van Deursen, Jan, Gores, Gregory J., Chen, Junjie, Lou, Zhenkun, Chini, Eduardo Nunes
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2810074/
https://ncbi.nlm.nih.gov/pubmed/20071779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI39319
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