Hedgehog Promotes Neovascularization in Pancreatic Cancers by Regulating Ang-1 and IGF-1 Expression in Bone-Marrow Derived Pro-Angiogenic Cells

BACKGROUND: The hedgehog (Hh) pathway has been implicated in the pathogenesis of cancer including pancreatic ductal adenocarcinoma (PDAC). Recent studies have suggested that the oncogenic function of Hh in PDAC involves signaling in the stromal cells rather than cell autonomous effects on the tumor...

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Bibliografski detalji
Glavni autori: Nakamura, Kazumasa, Sasajima, Junpei, Mizukami, Yusuke, Sugiyama, Yoshiaki, Yamazaki, Madoka, Fujii, Rie, Kawamoto, Toru, Koizumi, Kazuya, Sato, Kazuya, Fujiya, Mikihiro, Sasaki, Katsunori, Tanno, Satoshi, Okumura, Toshikatsu, Shimizu, Norihiko, Kawabe, Jun-ichi, Karasaki, Hidenori, Kono, Toru, Ii, Masaaki, Bardeesy, Nabeel, Chung, Daniel C., Kohgo, Yutaka
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2010
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2809097/
https://ncbi.nlm.nih.gov/pubmed/20098680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008824
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