The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

The PTEN/MMAC1 phosphatase is a tumor suppressor gene implicated in a wide range of human cancers. Here we provide biochemical and functional evidence that PTEN/MMAC1 acts a negative regulator of the phosphoinositide 3-kinase (PI3-kinase)/Akt pathway. PTEN/MMAC1 impairs activation of endogenous Akt...

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Cyhoeddwyd yn:	Proc Natl Acad Sci U S A
Prif Awduron:	Wu, Xinyi, Senechal, Kristen, Neshat, Mehran S., Whang, Young E., Sawyers, Charles L.
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	National Academy of Sciences 1998
Pynciau:	Biological Sciences
Mynediad Ar-lein:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC28087/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9861013/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.26.15587
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