Hypothalamic-Specific Manipulation of Fto, the Ortholog of the Human Obesity Gene FTO, Affects Food Intake in Rats

Sequence variants in the first intron of FTO are strongly associated with human obesity and human carriers of the risk alleles show evidence for increased appetite and food intake. Mice globally lacking Fto display a complex phenotype characterised by both increased energy expenditure and increased...

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Detaylı Bibliyografya
Asıl Yazarlar: Tung, Yi-Chun Loraine, Ayuso, Eduard, Shan, Xiaoye, Bosch, Fatima, O'Rahilly, Stephen, Coll, Anthony P., Yeo, Giles S. H.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2010
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2808248/
https://ncbi.nlm.nih.gov/pubmed/20098739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008771
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