Preeclampsia : 2-Methoxyestradiol Induces Cytotrophoblast Invasion and Vascular Development Specifically under Hypoxic Conditions

Inadequate invasion of the uterus by cytotrophoblasts is speculated to result in pregnancy-induced disorders such as preeclampsia. However, the molecular mechanisms that govern appropriate invasion of cytotrophoblasts are unknown. Here, we demonstrate that under low-oxygen conditions (2.5% oxygen),...

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Detalhes bibliográficos
Main Authors: Lee, Soo Bong, Wong, Amy P., Kanasaki, Keizo, Xu, Yong, Shenoy, Vivek K., McElrath, Thomas F., Whitesides, George M., Kalluri, Raghu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2010
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2808078/
https://ncbi.nlm.nih.gov/pubmed/20075204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090513
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