eNOS Knockout Mice with Advanced Diabetic Nephropathy Have Less Benefit from Renin-Angiotensin Blockade than from Aldosterone Receptor Antagonists

While blockade of the renin angiotensin system (RAS) is beneficial in treating many patients with diabetic nephropathy, some patients show a poor response. We hypothesized that the poor response of RAS blockade is attributed to inability to stimulate endothelial nitric oxide. Recently, we reported t...

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Bibliographic Details
Main Authors: Kosugi, Tomoki, Heinig, Marcelo, Nakayama, Takahiro, Matsuo, Seiichi, Nakagawa, Takahiko
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2010
Subjects:
Regular Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2808070/
https://ncbi.nlm.nih.gov/pubmed/20042665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090578
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