The first chemical synthesis of novel MeO-3-GlcUA derivative of hyaluronan-based disaccharide to elucidate the catalytic mechanism of hyaluronic acid synthases (HASs)

The first chemical synthesis of MeO-3-GlcUAβ(1→3)GlcNAc-UDP to elucidate the catalytic mechanism of hyaluronic acid synthases (HASs) is described. Construction of the desired β(1→3)-linked disaccharide 10 was achieved very efficiently by coupling MeO-3-GlcUA donor 3 with the suitable protected GlcNT...

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Bibliographic Details
Main Authors: Wei, Guohua, Kumar, Vipin, Xue, Jun, Locke, Robert D., Matta, Khushi L.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2808046/
https://ncbi.nlm.nih.gov/pubmed/20161585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2009.09.042
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