[6S]-5-methyltetrahydrofolate increases plasma folate more effectively than folic acid in women with the homozygous or wild-type 677C→T polymorphism of methylenetetrahydrofolate reductase

BACKGROUND AND PURPOSE: 5,10-Methylenetetrahydrofolate reductase (MTHFR) is responsible for the synthesis of 5-methyltetrahydrofolate (5-MTHF). The 677C→T mutation of MTHFR reduces the activity of this enzyme. The aim of this study was, first, to compare pharmacokinetic parameters of [6S]-5-MTHF and...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Prinz-Langenohl, R, Brämswig, S, Tobolski, O, Smulders, YM, Smith, DEC, Finglas, PM, Pietrzik, K
Format: Artigo
Langue:Inglês
Publié: Blackwell Publishing Ltd 2009
Sujets:
Research Papers
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807663/
https://ncbi.nlm.nih.gov/pubmed/19917061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2009.00492.x
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