The benzoxathiolone LYR-71 down-regulates interferon-γ-inducible pro-inflammatory genes by uncoupling tyrosine phosphorylation of STAT-1 in macrophages

BACKGROUND AND PURPOSE: Benzoxathiolone derivatives have shown anti-inflammatory and immunomodulatory potential in acne and psoriatic disorders. However, little is known about the molecular basis for these pharmacological effects. In this study, we decided to investigate the anti-inflammatory action...

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Detalhes bibliográficos
Main Authors: Chung, E-Y, Kim, B-H, Lee, I-J, Roh, E, Oh, S-J, Kwak, J-A, Lee, Y-R, Ahn, B, Nam, S-Y, Han, S-B, Kim, Y
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2009
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807659/
https://ncbi.nlm.nih.gov/pubmed/19922538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2009.00496.x
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