Elevated PAI-1 is associated with poor clinical outcomes in pediatric patients with acute lung injury

PURPOSE: Deposition of fibrin in the alveolar space is a hallmark of acute lung injury (ALI). Plasminogen activator inhibitor-1 (PAI-1) is an antifibrinolytic agent that is activated during inflammation. Increased plasma and pulmonary edema fluid levels of PAI-1 are associated with increased mortali...

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Hlavní autoři: Sapru, Anil, Curley, Martha A. Q., Brady, Sandra, Matthay, Michael A., Flori, Heidi
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer-Verlag 2009
Témata:
Experimental
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807603/
https://ncbi.nlm.nih.gov/pubmed/19855955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00134-009-1690-2
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