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Uracil DNA Glycosylase Activity on Nucleosomal DNA Depends on Rotational Orientation of Targets
The activity of uracil DNA glycosylases (UDGs), which recognize and excise uracil bases from DNA, has been well characterized on naked DNA substrates but less is known about activity in chromatin. We therefore prepared a set of model nucleosome substrates in which single thymidine residues were repl...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2807341/ https://ncbi.nlm.nih.gov/pubmed/19933279 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.073544 |
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